Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7865.016 | 0.7922 | 0.7578 | 1.8047 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7865.016 | 1.1087 | 1.1177 | 1.8047 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7865.016 | 1.0474 | 1.0520 | 1.8047 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7865.016 | 0.8710 | 0.8527 | 1.8047 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7865.016 | 1.0611 | 1.0668 | 1.8047 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7865.016 | 1.1723 | 1.1842 | 1.8047 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9536.019 | 1.0464 | 1.0590 | 1.5595 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 9536.019 | 0.9600 | 0.9483 | 1.5595 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 9536.019 | 0.9500 | 0.9352 | 1.5595 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9536.019 | 0.9052 | 0.8763 | 1.5595 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 9536.019 | 0.9116 | 0.8847 | 1.5595 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 9536.019 | 0.9020 | 0.8720 | 1.5595 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 9536.019 | 0.8550 | 0.8088 | 1.5595 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9536.019 | 0.8296 | 0.7743 | 1.5595 | ||
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9536.019 | 0.1257 | -0.4711 | 1.5595 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9039.016 | 0.9770 | 0.9168 | 0.5468 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 9039.016 | 0.9819 | 0.9345 | 0.5468 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 9039.016 | 0.9466 | 0.8091 | 0.5468 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9039.016 | 0.9542 | 0.8358 | 0.5468 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 9039.016 | 1.0421 | 1.1567 | 0.5468 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 9039.016 | 0.8943 | 0.6305 | 0.5468 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 9039.016 | 0.9539 | 0.8344 | 0.5468 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9039.016 | 0.9242 | 0.7315 | 0.5468 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9039.016 | 0.7708 | 0.2424 | 0.5468 | ||
| MCF 10A | NM | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7867.016 | 1.0408 | 1.0356 | 2.2657 |