Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 10441.066 | 0.3777 | -0.1366 | 1.1591 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7447.066 | 1.0154 | 1.0195 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7447.066 | 1.0891 | 1.1109 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7447.066 | 1.0182 | 1.0230 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7447.066 | 1.0847 | 1.1055 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7447.066 | 1.0285 | 1.0359 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7447.066 | 1.0062 | 1.0079 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7447.066 | 0.9918 | 0.9897 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7447.066 | 0.8460 | 0.7993 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7447.066 | 0.2528 | -0.1618 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7448.066 | 0.9139 | 0.9344 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7448.066 | 0.9671 | 0.9754 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7448.066 | 0.9414 | 0.9558 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7448.066 | 0.9809 | 0.9857 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7448.066 | 0.9836 | 0.9878 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7448.066 | 0.9287 | 0.9460 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7448.066 | 0.9265 | 0.9443 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7448.066 | 0.8266 | 0.8638 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7448.066 | 0.3091 | 0.2947 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7449.066 | 0.9897 | 0.9894 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7449.066 | 1.0456 | 1.0459 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7449.066 | 0.9729 | 0.9722 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7449.066 | 0.9981 | 0.9981 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7449.066 | 1.0407 | 1.0410 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7449.066 | 0.9677 | 0.9668 | 1.9622 |