Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7449.066 | 0.9781 | 0.9776 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7449.066 | 0.8607 | 0.8528 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7449.066 | 0.5147 | 0.4258 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 10442.066 | 0.9928 | 0.9912 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 10442.066 | 0.9936 | 0.9922 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 10442.066 | 0.9335 | 0.9184 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 10442.066 | 1.0019 | 1.0023 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 10442.066 | 0.9746 | 0.9691 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 10442.066 | 0.9723 | 0.9663 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 10442.066 | 0.9425 | 0.9295 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 10442.066 | 0.9621 | 0.9538 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 10442.066 | 0.1632 | -0.3326 | 1.6519 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7450.066 | 0.9870 | 0.9891 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7450.066 | 0.9544 | 0.9613 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7450.066 | 0.9310 | 0.9409 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7450.066 | 1.0549 | 1.0453 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7450.066 | 0.9541 | 0.9610 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7450.066 | 0.9921 | 0.9933 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7450.066 | 0.9703 | 0.9749 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7450.066 | 0.9531 | 0.9601 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7450.066 | 0.7467 | 0.7696 | 2.3863 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7451.066 | 0.9572 | 0.9568 | 2.0040 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7451.066 | 0.9575 | 0.9571 | 2.0040 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7451.066 | 1.0053 | 1.0053 | 2.0040 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7451.066 | 1.0125 | 1.0124 | 2.0040 |