Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7451.066 | 1.0155 | 1.0154 | 2.0040 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7451.066 | 1.0182 | 1.0181 | 2.0040 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7451.066 | 0.9555 | 0.9551 | 2.0040 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7451.066 | 0.9564 | 0.9560 | 2.0040 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7451.066 | 0.0795 | -0.4347 | 2.0040 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7452.066 | 0.9435 | 0.9225 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7452.066 | 1.0417 | 1.0563 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7452.066 | 0.9490 | 0.9301 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7452.066 | 0.9692 | 0.9580 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7452.066 | 0.9986 | 0.9981 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7452.066 | 0.9476 | 0.9282 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7452.066 | 0.9395 | 0.9170 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7452.066 | 0.8882 | 0.8452 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7452.066 | 0.3016 | -0.1140 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7453.066 | 1.0422 | 1.0603 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7453.066 | 1.0067 | 1.0096 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7453.066 | 1.0092 | 1.0133 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7453.066 | 1.0783 | 1.1114 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7453.066 | 1.0458 | 1.0655 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7453.066 | 1.0042 | 1.0061 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7453.066 | 1.0383 | 1.0549 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7453.066 | 0.8916 | 0.8416 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7453.066 | 0.4551 | 0.1353 | 1.3901 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7454.066 | 0.8564 | 0.7710 | 1.2748 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7454.066 | 0.8921 | 0.8287 | 1.2748 |