Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5904.066 | 0.9583 | 0.9172 | 1.0078 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5904.066 | 0.9944 | 0.9888 | 1.0078 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5904.066 | 0.6972 | 0.3983 | 1.0078 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 10385.066 | 0.9598 | 0.8946 | 0.7592 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 10385.066 | 0.9887 | 0.9702 | 0.7592 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 10385.066 | 0.9886 | 0.9699 | 0.7592 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 10385.066 | 0.9971 | 0.9924 | 0.7592 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 10385.066 | 1.0095 | 1.0252 | 0.7592 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 10385.066 | 0.9994 | 0.9983 | 0.7592 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 10385.066 | 0.9743 | 0.9327 | 0.7592 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 10385.066 | 0.9825 | 0.9541 | 0.7592 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 10385.066 | 0.5163 | -0.1627 | 0.7592 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5905.066 | 1.0050 | 1.0130 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5905.066 | 1.0112 | 1.0293 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5905.066 | 1.0149 | 1.0392 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5905.066 | 1.0249 | 1.0654 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5905.066 | 1.1211 | 1.3227 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5905.066 | 0.9954 | 0.9878 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5905.066 | 1.0290 | 1.0761 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5905.066 | 0.9353 | 0.8324 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5905.066 | 0.5097 | -0.1724 | 0.7639 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5906.066 | 0.9908 | 0.9767 | 0.7892 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5906.066 | 1.0339 | 1.0862 | 0.7892 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5906.066 | 0.9747 | 0.9360 | 0.7892 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5906.066 | 0.9499 | 0.8739 | 0.7892 |