Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5901.066 | 0.1562 | -0.2302 | 1.9445 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5902.066 | 0.9643 | 0.9392 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5902.066 | 1.0149 | 1.0252 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5902.066 | 1.0334 | 1.0566 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5902.066 | 0.9737 | 0.9552 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5902.066 | 1.0707 | 1.1195 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5902.066 | 0.9782 | 0.9629 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5902.066 | 1.0073 | 1.0124 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5902.066 | 0.9763 | 0.9596 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5902.066 | 0.3899 | -0.1012 | 1.1775 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5903.066 | 0.9678 | 0.9459 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5903.066 | 1.0413 | 1.0690 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5903.066 | 1.0054 | 1.0091 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5903.066 | 1.0110 | 1.0185 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5903.066 | 1.0132 | 1.0220 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5903.066 | 0.9642 | 0.9399 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5903.066 | 0.9662 | 0.9432 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5903.066 | 0.9604 | 0.9335 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5903.066 | 0.2225 | -0.4317 | 1.1945 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5904.066 | 0.9803 | 0.9610 | 1.0078 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5904.066 | 1.0085 | 1.0168 | 1.0078 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5904.066 | 0.9928 | 0.9857 | 1.0078 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5904.066 | 1.0064 | 1.0127 | 1.0078 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5904.066 | 1.0750 | 1.1487 | 1.0078 | |
| BT-20 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5904.066 | 0.9033 | 0.8081 | 1.0078 |