Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 12400.167 | 0.0126 | -0.9375 | 1.2627 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 12400.167 | 0.0115 | -0.9417 | 1.2627 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10694.154 | 1.0259 | 1.0223 | 2.3045 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.000427 | uM | 10694.154 | 0.9137 | 0.9232 | 2.3045 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.00213 | uM | 10694.154 | 1.0541 | 1.0462 | 2.3045 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0107 | uM | 10694.154 | 0.9858 | 0.9876 | 2.3045 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0533 | uM | 10694.154 | 1.0250 | 1.0215 | 2.3045 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.267 | uM | 10694.154 | 0.6783 | 0.6899 | 2.3045 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 1.33 | uM | 10694.154 | 0.0408 | -0.5008 | 2.3045 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 6.67 | uM | 10694.154 | 0.0135 | -0.6907 | 2.3045 | |
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 33.3 | uM | 10694.154 | 0.0099 | -0.7298 | 2.3045 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12319.167 | 0.9364 | 0.8990 | 1.2676 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12319.167 | 0.9958 | 0.9934 | 1.2676 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12319.167 | 0.9834 | 0.9738 | 1.2676 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12319.167 | 0.7232 | 0.5488 | 1.2676 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12319.167 | 0.5923 | 0.3231 | 1.2676 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12319.167 | 0.3565 | -0.1135 | 1.2676 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12319.167 | 0.0089 | -0.9519 | 1.2676 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12319.167 | 0.0216 | -0.9028 | 1.2676 | |
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12319.167 | 0.0180 | -0.9159 | 1.2676 | |
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12580.167 | 1.0236 | 1.0214 | 2.1970 | |
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.000427 | uM | 12580.167 | 0.9955 | 0.9959 | 2.1970 | |
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.00213 | uM | 12580.167 | 1.0337 | 1.0304 | 2.1970 | |
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0107 | uM | 12580.167 | 0.9565 | 0.9599 | 2.1970 | |
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0533 | uM | 12580.167 | 0.6774 | 0.6751 | 2.1970 |