Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.267 | uM | 12580.167 | 0.2432 | 0.0508 | 2.1970 | |
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 1.33 | uM | 12580.167 | 0.0278 | -0.6086 | 2.1970 | |
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 6.67 | uM | 12580.167 | 0.0153 | -0.7018 | 2.1970 | |
| MB 157 | Unknown | Unknown | LBH589 | HDAC | HDAC | 33.3 | uM | 12580.167 | 0.0135 | -0.7184 | 2.1970 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11056.154 | 0.9272 | 0.9491 | 2.9341 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 0.000427 | uM | 11056.154 | 1.0060 | 1.0041 | 2.9341 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 0.00213 | uM | 11056.154 | 0.9711 | 0.9801 | 2.9341 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 0.0107 | uM | 11056.154 | 1.0632 | 1.0422 | 2.9341 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 0.0533 | uM | 11056.154 | 0.8227 | 0.8713 | 2.9341 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 0.267 | uM | 11056.154 | 0.3002 | 0.3271 | 2.9341 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 1.33 | uM | 11056.154 | 0.0285 | -0.4049 | 2.9341 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 6.67 | uM | 11056.154 | 0.0104 | -0.5786 | 2.9341 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 33.3 | uM | 11056.154 | 0.0094 | -0.5925 | 2.9341 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12254.154 | 1.0925 | 1.1115 | 1.6307 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 0.000427 | uM | 12254.154 | 1.0568 | 1.0689 | 1.6307 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 0.00213 | uM | 12254.154 | 1.0815 | 1.0984 | 1.6307 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 0.0107 | uM | 12254.154 | 1.0889 | 1.1072 | 1.6307 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 0.0533 | uM | 12254.154 | 1.1319 | 1.1579 | 1.6307 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 0.267 | uM | 12254.154 | 1.0009 | 1.0011 | 1.6307 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 1.33 | uM | 12254.154 | 0.4417 | 0.2117 | 1.6307 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 6.67 | uM | 12254.154 | 0.1232 | -0.4463 | 1.6307 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 33.3 | uM | 12254.154 | 0.0688 | -0.6126 | 1.6307 | |
| MCF12A | NM | Basal B | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10817.154 | 1.0007 | 1.0009 | 1.4551 | |
| MCF12A | NM | Basal B | LBH589 | HDAC | HDAC | 0.000427 | uM | 10817.154 | 0.9656 | 0.9525 | 1.4551 | |
| MCF12A | NM | Basal B | LBH589 | HDAC | HDAC | 0.00213 | uM | 10817.154 | 1.0107 | 1.0147 | 1.4551 |