Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12056.154 | 0.0298 | -0.9572 | 0.9136 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12056.154 | 0.0400 | -0.9409 | 0.9136 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12178.154 | 1.0306 | 1.1199 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12178.154 | 1.0317 | 1.1244 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12178.154 | 1.1069 | 1.4343 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12178.154 | 1.0629 | 1.2504 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12178.154 | 0.9551 | 0.8298 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12178.154 | 0.3572 | -0.7270 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12178.154 | 0.0294 | -0.9978 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12178.154 | 0.0451 | -0.9950 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12178.154 | 0.0579 | -0.9919 | 0.5170 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12291.167 | 1.0244 | 1.0801 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12291.167 | 0.9682 | 0.8976 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12291.167 | 0.9840 | 0.9482 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12291.167 | 0.8650 | 0.5796 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12291.167 | 0.7809 | 0.3376 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12291.167 | 0.2167 | -0.8338 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12291.167 | 0.0189 | -0.9969 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12291.167 | 0.0311 | -0.9929 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12291.167 | 0.0342 | -0.9918 | 0.6147 | |
| BT-483 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10696.154 | 0.9823 | 0.9420 | 0.6070 | |
| BT-483 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 10696.154 | 0.9757 | 0.9207 | 0.6070 | |
| BT-483 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 10696.154 | 1.0077 | 1.0254 | 0.6070 | |
| BT-483 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 10696.154 | 0.9922 | 0.9742 | 0.6070 | |
| BT-483 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 10696.154 | 0.9139 | 0.7244 | 0.6070 |