Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11850.154 | 0.9600 | 0.9578 | 1.9115 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.000427 | uM | 11850.154 | 0.9599 | 0.9577 | 1.9115 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.00213 | uM | 11850.154 | 0.9739 | 0.9725 | 1.9115 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0107 | uM | 11850.154 | 0.9089 | 0.9025 | 1.9115 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0533 | uM | 11850.154 | 0.4305 | 0.2869 | 1.9115 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.267 | uM | 11850.154 | 0.0400 | -0.6285 | 1.9115 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 1.33 | uM | 11850.154 | 0.0044 | -0.8836 | 1.9115 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 6.67 | uM | 11850.154 | 0.0089 | -0.8313 | 1.9115 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 33.3 | uM | 11850.154 | 0.0063 | -0.8586 | 1.9115 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10873.154 | 1.0089 | 1.0152 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 10873.154 | 0.9752 | 0.9573 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 10873.154 | 0.9905 | 0.9837 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 10873.154 | 1.0118 | 1.0203 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 10873.154 | 0.8434 | 0.7280 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 10873.154 | 0.1581 | -0.5896 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 10873.154 | 0.0077 | -0.9694 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 10873.154 | 0.0125 | -0.9534 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 10873.154 | 0.0135 | -0.9505 | 1.1648 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12400.167 | 0.9741 | 0.9588 | 1.2627 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 12400.167 | 0.9780 | 0.9651 | 1.2627 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 12400.167 | 1.0442 | 1.0696 | 1.2627 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 12400.167 | 1.0151 | 1.0238 | 1.2627 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 12400.167 | 0.8096 | 0.6919 | 1.2627 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 12400.167 | 0.0654 | -0.7694 | 1.2627 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 12400.167 | 0.0078 | -0.9572 | 1.2627 |