Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7443.098 | 0.9723 | 0.9399 | 0.9189 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7443.098 | 1.0083 | 1.0182 | 0.9189 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7444.098 | 0.9856 | 0.9703 | 0.9681 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7444.098 | 0.9382 | 0.8724 | 0.9681 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7444.098 | 0.9601 | 0.9177 | 0.9681 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7444.098 | 0.9565 | 0.9102 | 0.9681 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7444.098 | 0.9572 | 0.9117 | 0.9681 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7444.098 | 0.9122 | 0.8188 | 0.9681 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7444.098 | 0.9144 | 0.8234 | 0.9681 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7444.098 | 0.9760 | 0.9505 | 0.9681 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7444.098 | 0.7854 | 0.5583 | 0.9681 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7448.098 | 1.0323 | 1.0221 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7448.098 | 0.9943 | 0.9960 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7448.098 | 0.9994 | 0.9996 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7448.098 | 1.0328 | 1.0225 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7448.098 | 1.0688 | 1.0466 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7448.098 | 0.9538 | 0.9675 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7448.098 | 0.9217 | 0.9443 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7448.098 | 0.5744 | 0.6506 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7448.098 | 0.5084 | 0.5823 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7449.098 | 1.0527 | 1.0558 | 1.8675 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7449.098 | 1.0761 | 1.0801 | 1.8675 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7449.098 | 1.0709 | 1.0747 | 1.8675 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7449.098 | 1.0524 | 1.0555 | 1.8675 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7449.098 | 1.0249 | 1.0265 | 1.8675 |