Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5896.084 | 0.1301 | -0.4772 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5896.084 | 0.1136 | -0.5218 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5896.084 | 0.1324 | -0.4711 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 333 | uM | 5896.084 | 0.1448 | -0.4392 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5897.085 | 1.0243 | 1.0391 | 1.2392 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5897.085 | 0.9785 | 0.9652 | 1.2392 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5897.085 | 0.9975 | 0.9960 | 1.2392 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5897.085 | 0.1433 | -0.5830 | 1.2392 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5897.085 | 0.1218 | -0.6342 | 1.2392 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5897.085 | 0.1298 | -0.6151 | 1.2392 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5897.085 | 0.1358 | -0.6008 | 1.2392 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5897.085 | 0.1358 | -0.6008 | 1.2392 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 333 | uM | 5897.085 | 0.1286 | -0.6179 | 1.2392 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5898.085 | 0.9529 | 0.8677 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5898.085 | 0.9397 | 0.8310 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5898.085 | 0.8934 | 0.7044 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5898.085 | 0.7374 | 0.2982 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5898.085 | 0.7149 | 0.2422 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5898.085 | 0.7341 | 0.2899 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5898.085 | 0.7214 | 0.2583 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5898.085 | 0.7305 | 0.2809 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5898.085 | 0.6935 | 0.1899 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5899.084 | 0.9761 | 0.9570 | 1.1144 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5899.084 | 0.9677 | 0.9420 | 1.1144 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5899.084 | 0.9477 | 0.9058 | 1.1144 |