Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Mebendazole | 13.3 | uM | 13595.174 | 0.4831 | 0.3524 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Mebendazole | 66.7 | uM | 13595.174 | 0.4148 | 0.2460 | 1.8596 | |||
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5894.084 | 1.0144 | 1.0181 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5894.084 | 0.9321 | 0.9135 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5894.084 | 0.9955 | 0.9943 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5894.084 | 0.2291 | -0.2083 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5894.084 | 0.1742 | -0.3335 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5894.084 | 0.1726 | -0.3373 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5894.084 | 0.1782 | -0.3239 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5894.084 | 0.1887 | -0.2992 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 333 | uM | 5894.084 | 0.2017 | -0.2692 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5895.085 | 1.0699 | 1.0961 | 1.4396 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5895.085 | 1.0111 | 1.0154 | 1.4396 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5895.085 | 0.9696 | 0.9576 | 1.4396 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5895.085 | 0.2885 | -0.1567 | 1.4396 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5895.085 | 0.2093 | -0.3251 | 1.4396 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5895.085 | 0.2141 | -0.3145 | 1.4396 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5895.085 | 0.1990 | -0.3484 | 1.4396 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5895.085 | 0.2203 | -0.3007 | 1.4396 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 333 | uM | 5895.085 | 0.2174 | -0.3071 | 1.4396 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5896.084 | 1.0073 | 1.0096 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5896.084 | 0.9560 | 0.9416 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5896.084 | 0.7951 | 0.7199 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5896.084 | 0.1364 | -0.4607 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5896.084 | 0.1172 | -0.5120 | 1.5200 |