Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5899.084 | 1.0530 | 1.0949 | 1.1144 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5899.084 | 0.9307 | 0.8752 | 1.1144 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5899.084 | 0.8893 | 0.8002 | 1.1144 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5899.084 | 0.9185 | 0.8531 | 1.1144 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5899.084 | 0.8887 | 0.7991 | 1.1144 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5899.084 | 0.8563 | 0.7402 | 1.1144 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5900.085 | 1.0523 | 1.0390 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5900.085 | 0.9768 | 0.9823 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5900.085 | 0.8936 | 0.9166 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5900.085 | 0.3435 | 0.3340 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5900.085 | 0.2828 | 0.2394 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5900.085 | 0.2892 | 0.2498 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5900.085 | 0.2737 | 0.2240 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5900.085 | 0.2447 | 0.1731 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5900.085 | 0.2645 | 0.2082 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5901.084 | 1.0389 | 1.0443 | 1.7402 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5901.084 | 1.0294 | 1.0336 | 1.7402 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5901.084 | 0.8313 | 0.7985 | 1.7402 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5901.084 | 0.7473 | 0.6918 | 1.7402 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5901.084 | 0.6509 | 0.5627 | 1.7402 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5901.084 | 0.7220 | 0.6586 | 1.7402 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5901.084 | 0.7424 | 0.6853 | 1.7402 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5901.084 | 0.6780 | 0.5997 | 1.7402 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5901.084 | 0.6662 | 0.5836 | 1.7402 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5902.084 | 1.1289 | 1.1875 | 1.3532 |