Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5902.084 | 0.9814 | 0.9725 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5902.084 | 0.9313 | 0.8975 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5902.084 | 0.9795 | 0.9696 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5902.084 | 1.0472 | 1.0693 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5902.084 | 1.1392 | 1.2022 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5902.084 | 1.1316 | 1.1913 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5902.084 | 1.0816 | 1.1193 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 5902.084 | 0.9963 | 0.9945 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5903.084 | 0.9341 | 0.8903 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5903.084 | 1.0024 | 1.0040 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5903.084 | 0.9571 | 0.9288 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5903.084 | 0.9949 | 0.9916 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5903.084 | 0.9656 | 0.9429 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5903.084 | 1.0130 | 1.0214 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5903.084 | 1.0308 | 1.0508 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5903.084 | 1.0062 | 1.0102 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 5903.084 | 1.0265 | 1.0437 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5904.085 | 1.1040 | 1.1683 | 1.2247 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5904.085 | 0.9757 | 0.9603 | 1.2247 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5904.085 | 1.0349 | 1.0569 | 1.2247 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5904.085 | 1.0044 | 1.0072 | 1.2247 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5904.085 | 1.1368 | 1.2208 | 1.2247 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5904.085 | 1.0992 | 1.1605 | 1.2247 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5904.085 | 1.1204 | 1.1946 | 1.2247 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5904.085 | 1.1377 | 1.2221 | 1.2247 |