Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10816.149 | 1.4146 | 3.2899 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12319.166 | 0.9278 | 0.8942 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 12319.166 | 0.7407 | 0.6087 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12319.166 | 1.0112 | 1.0162 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 12319.166 | 0.8549 | 0.7851 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 12319.166 | 0.7682 | 0.6519 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 12319.166 | 1.0848 | 1.1217 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 12319.166 | 0.6377 | 0.4432 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 12319.166 | 0.9132 | 0.8725 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 12319.166 | 0.7431 | 0.6126 | 1.3789 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12580.166 | 1.0334 | 1.0355 | 1.8686 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.000427 | uM | 12580.166 | 1.0232 | 1.0247 | 1.8686 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.00213 | uM | 12580.166 | 1.0961 | 1.1006 | 1.8686 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.0107 | uM | 12580.166 | 1.0558 | 1.0590 | 1.8686 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.0533 | uM | 12580.166 | 1.1236 | 1.1287 | 1.8686 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.267 | uM | 12580.166 | 1.1094 | 1.1142 | 1.8686 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 1.33 | uM | 12580.166 | 1.0436 | 1.0462 | 1.8686 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 6.67 | uM | 12580.166 | 0.8757 | 0.8629 | 1.8686 | |
| MB 157 | Unknown | Unknown | L-779450 | BRAF | MAPK | 33.3 | uM | 12580.166 | 0.3848 | 0.1997 | 1.8686 | |
| MCF 10A | NM | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 11056.149 | 1.0024 | 1.0016 | 2.9204 | |
| MCF 10A | NM | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 11056.149 | 1.0446 | 1.0301 | 2.9204 | |
| MCF 10A | NM | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 11056.149 | 1.0030 | 1.0020 | 2.9204 | |
| MCF 10A | NM | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 11056.149 | 1.1002 | 1.0665 | 2.9204 | |
| MCF 10A | NM | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 11056.149 | 0.9993 | 0.9995 | 2.9204 | |
| MCF 10A | NM | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 11056.149 | 1.0686 | 1.0459 | 2.9204 |