Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 11938.154 | 0.6076 | -0.0846 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 11938.154 | 0.3393 | -0.6330 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 11938.154 | 0.0134 | -0.9977 | 0.6375 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 11660.154 | 0.9580 | 0.9105 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 11660.154 | 0.8995 | 0.7866 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 11660.154 | 0.9257 | 0.8421 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 11660.154 | 0.9529 | 0.8998 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 11660.154 | 0.9347 | 0.8612 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 11660.154 | 0.9078 | 0.8041 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 11660.154 | 0.7616 | 0.4965 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 11660.154 | 0.5942 | 0.1488 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 11660.154 | 0.3579 | -0.3306 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12003.167 | 0.8892 | 0.8001 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12003.167 | 0.8519 | 0.7323 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12003.167 | 0.9411 | 0.8941 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12003.167 | 0.9299 | 0.8740 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12003.167 | 0.9202 | 0.8563 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12003.167 | 0.9037 | 0.8265 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12003.167 | 0.7249 | 0.4990 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12003.167 | 0.5604 | 0.1902 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12003.167 | 0.2751 | -0.3709 | 1.1158 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 11939.154 | 0.8946 | 0.8749 | 1.7246 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 11939.154 | 0.8863 | 0.8648 | 1.7246 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 11939.154 | 0.9393 | 0.9286 | 1.7246 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 11939.154 | 0.9478 | 0.9387 | 1.7246 |