Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 11939.154 | 0.8834 | 0.8612 | 1.7246 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 11939.154 | 0.6425 | 0.5475 | 1.7246 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 11939.154 | 0.4723 | 0.2946 | 1.7246 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 11939.154 | 0.3681 | 0.1203 | 1.7246 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 11939.154 | 0.0751 | -0.5541 | 1.7246 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 0.000256 | uM | 7812.029 | 1.3310 | 1.6905 | 0.9642 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 0.00128 | uM | 7812.029 | 1.2222 | 1.4626 | 0.9642 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 0.0064 | uM | 7812.029 | 1.0144 | 1.0298 | 0.9642 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 0.032 | uM | 7812.029 | 1.1780 | 1.3704 | 0.9642 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 0.16 | uM | 7812.029 | 1.2326 | 1.4844 | 0.9642 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 0.8 | uM | 7812.029 | 1.1048 | 1.2178 | 0.9642 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 4 | uM | 7812.029 | 1.2833 | 1.5906 | 0.9642 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 20 | uM | 7812.029 | 1.2506 | 1.5220 | 0.9642 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 100 | uM | 7812.029 | 1.1854 | 1.3858 | 0.9642 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 0.000256 | uM | 7898.029 | 1.4188 | 2.2667 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 0.00128 | uM | 7898.029 | 1.1138 | 1.3265 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 0.0064 | uM | 7898.029 | 1.2843 | 1.8407 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 0.032 | uM | 7898.029 | 1.1673 | 1.4847 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 0.16 | uM | 7898.029 | 1.3428 | 2.0240 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 0.8 | uM | 7898.029 | 1.2183 | 1.6381 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 4 | uM | 7898.029 | 1.3698 | 2.1094 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 20 | uM | 7898.029 | 1.4949 | 2.5151 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 100 | uM | 7898.029 | 1.1439 | 1.4152 | 0.7130 | |
| 184A1 | NM | Basal | Mebendazole | 0.000171 | uM | 12684.174 | 1.0619 | 1.0837 | 1.4645 | |||
| 184A1 | NM | Basal | Mebendazole | 0.000853 | uM | 12684.174 | 1.0123 | 1.0167 | 1.4645 |