Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 4 | uM | 10643.142 | 0.4991 | -0.4791 | 0.5166 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 20 | uM | 10643.142 | 0.0260 | -0.9983 | 0.5166 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 100 | uM | 10643.142 | 0.0043 | -1.0000 | 0.5166 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10999.154 | 1.0103 | 1.0294 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 10999.154 | 1.1280 | 1.3739 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 10999.154 | 1.0134 | 1.0382 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 10999.154 | 1.0302 | 1.0866 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 10999.154 | 0.9675 | 0.9080 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 10999.154 | 0.8512 | 0.5902 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 10999.154 | 0.6716 | 0.1351 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 10999.154 | 0.3622 | -0.5286 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 10999.154 | 0.0266 | -0.9885 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12379.167 | 1.0037 | 1.0141 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12379.167 | 1.0167 | 1.0646 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12379.167 | 1.0293 | 1.1139 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12379.167 | 0.9785 | 0.9184 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12379.167 | 1.0155 | 1.0599 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12379.167 | 0.9011 | 0.6377 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12379.167 | 0.5160 | -0.4382 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12379.167 | 0.0937 | -0.9787 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12379.167 | 0.0087 | -0.9998 | 0.5212 | |
| MDA-MB-415 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10938.154 | 0.6530 | 0.3288 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 10938.154 | 0.8564 | 0.7237 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 10938.154 | 0.9009 | 0.8095 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 10938.154 | 0.8452 | 0.7021 | 1.0425 |