Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 10872.154 | 0.0118 | -0.9168 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12523.167 | 0.9723 | 0.9466 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12523.167 | 0.9597 | 0.9225 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12523.167 | 0.9824 | 0.9661 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12523.167 | 0.9872 | 0.9753 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12523.167 | 0.9648 | 0.9323 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12523.167 | 0.9135 | 0.8333 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12523.167 | 0.4053 | -0.1609 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12523.167 | 0.4600 | -0.0522 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12523.167 | 0.0179 | -0.9582 | 1.0398 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12239.154 | 0.9660 | 0.9688 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12239.154 | 0.9417 | 0.9461 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12239.154 | 1.0233 | 1.0210 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12239.154 | 0.9938 | 0.9944 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12239.154 | 0.9042 | 0.9106 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12239.154 | 0.3508 | 0.2428 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12239.154 | 0.0731 | -0.3903 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12239.154 | 0.0286 | -0.6023 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12239.154 | 0.0123 | -0.7290 | 2.2015 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 11849.154 | 0.9890 | 0.9815 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 11849.154 | 1.0944 | 1.1571 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 11849.154 | 0.9885 | 0.9806 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 11849.154 | 1.0878 | 1.1463 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 11849.154 | 0.9072 | 0.8431 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 11849.154 | 0.8426 | 0.7324 | 1.1927 |