Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 11849.154 | 0.5661 | 0.2412 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 11849.154 | 0.2581 | -0.3574 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 11849.154 | 0.0319 | -0.8887 | 1.1927 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 11055.154 | 0.9783 | 0.9755 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 11055.154 | 0.9567 | 0.9507 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 11055.154 | 0.9513 | 0.9446 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 11055.154 | 1.0205 | 1.0230 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 11055.154 | 0.9272 | 0.9167 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 11055.154 | 0.8760 | 0.8563 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 11055.154 | 0.9461 | 0.9386 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 11055.154 | 0.4260 | 0.2372 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 11055.154 | 0.0150 | -0.8120 | 1.7768 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10996.154 | 0.9645 | 0.8664 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 10996.154 | 0.9749 | 0.9051 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 10996.154 | 0.9564 | 0.8365 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 10996.154 | 1.0320 | 1.1243 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 10996.154 | 1.0652 | 1.2568 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 10996.154 | 1.0728 | 1.2876 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 10996.154 | 0.9228 | 0.7151 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 10996.154 | 0.3713 | -0.6991 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 10996.154 | 0.0536 | -0.9926 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12192.154 | 0.9615 | 0.8591 | 0.5377 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12192.154 | 1.0561 | 1.2135 | 0.5377 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12192.154 | 0.9670 | 0.8790 | 0.5377 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12192.154 | 0.9743 | 0.9054 | 0.5377 |