Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12003.167 | 0.3586 | -0.2023 | 1.1158 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11939.154 | 0.9634 | 0.9572 | 1.7246 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 11939.154 | 0.9469 | 0.9377 | 1.7246 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 11939.154 | 0.9808 | 0.9777 | 1.7246 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 11939.154 | 0.9332 | 0.9214 | 1.7246 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 11939.154 | 0.7544 | 0.6985 | 1.7246 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 11939.154 | 0.2612 | -0.0817 | 1.7246 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 11939.154 | 0.0511 | -0.6434 | 1.7246 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 11939.154 | 0.0379 | -0.7000 | 1.7246 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 11939.154 | 0.0293 | -0.7416 | 1.7246 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12509.167 | 1.0245 | 1.0343 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12509.167 | 0.9614 | 0.9455 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12509.167 | 1.0763 | 1.1058 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12509.167 | 1.0597 | 1.0830 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12509.167 | 0.9419 | 0.9177 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12509.167 | 1.0663 | 1.0922 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12509.167 | 0.7108 | 0.5742 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12509.167 | 0.0613 | -0.7180 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12509.167 | 0.0210 | -0.8669 | 1.4256 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12566.167 | 1.0434 | 1.0540 | 1.5941 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12566.167 | 0.9842 | 0.9801 | 1.5941 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12566.167 | 0.9674 | 0.9588 | 1.5941 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12566.167 | 0.9201 | 0.8982 | 1.5941 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12566.167 | 0.8830 | 0.8498 | 1.5941 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12566.167 | 0.7126 | 0.6170 | 1.5941 |