Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Methylglyoxal | 2160 | uM | 13078.184 | 0.7365 | 0.2756 | 0.6800 | |||
| UACC-812 | HER2amp | Luminal | Methylglyoxal | 10800 | uM | 13078.184 | 0.2887 | -0.6781 | 0.6800 | |||
| UACC-812 | HER2amp | Luminal | Methylglyoxal | 54000 | uM | 13078.184 | 0.0069 | -0.9987 | 0.6800 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 0.138 | uM | 13627.184 | 0.9131 | 0.8343 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 0.691 | uM | 13627.184 | 0.8880 | 0.7864 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 3.46 | uM | 13627.184 | 0.9232 | 0.8536 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 17.3 | uM | 13627.184 | 0.9032 | 0.8154 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 86.4 | uM | 13627.184 | 0.8859 | 0.7822 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 432 | uM | 13627.184 | 0.8806 | 0.7721 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 2160 | uM | 13627.184 | 0.6866 | 0.3986 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 10800 | uM | 13627.184 | 0.1922 | -0.5835 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 54000 | uM | 13627.184 | 0.8529 | 0.7191 | 1.0513 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 0.138 | uM | 13525.184 | 0.9544 | 0.9473 | 1.7478 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 0.691 | uM | 13525.184 | 0.9498 | 0.9419 | 1.7478 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 3.46 | uM | 13525.184 | 0.9883 | 0.9866 | 1.7478 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 17.3 | uM | 13525.184 | 0.9769 | 0.9735 | 1.7478 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 86.4 | uM | 13525.184 | 0.9636 | 0.9581 | 1.7478 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 432 | uM | 13525.184 | 0.9205 | 0.9074 | 1.7478 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 2160 | uM | 13525.184 | 0.5025 | 0.3490 | 1.7478 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 10800 | uM | 13525.184 | 0.2607 | -0.0733 | 1.7478 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 54000 | uM | 13525.184 | 0.0123 | -0.8388 | 1.7478 | |||
| 184A1 | NM | Basal | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 12509.17 | 1.0092 | 1.0131 | 1.3955 | |
| 184A1 | NM | Basal | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 12509.17 | 1.0092 | 1.0131 | 1.3955 | |
| 184A1 | NM | Basal | MG-132 | Proteasome | Proteasome | 0.000853 | uM | 12509.17 | 0.9628 | 0.9464 | 1.3955 | |
| 184A1 | NM | Basal | MG-132 | Proteasome | Proteasome | 0.000853 | uM | 12509.17 | 0.9628 | 0.9464 | 1.3955 |