Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10880.148 | 0.8114 | 0.7723 | 1.7293 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10880.148 | 0.2684 | -0.0652 | 1.7293 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10880.148 | 0.2270 | -0.1515 | 1.7293 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10880.148 | 0.2103 | -0.1883 | 1.7293 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10880.148 | 0.2310 | -0.1429 | 1.7293 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10581.135 | 0.9392 | 0.7359 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10581.135 | 0.9779 | 0.9015 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10581.135 | 0.9370 | 0.7265 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10581.135 | 1.0343 | 1.1585 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10581.135 | 1.0739 | 1.3495 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10581.135 | 0.9737 | 0.8830 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10581.135 | 0.7427 | 0.0212 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10581.135 | 0.2778 | -0.8893 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10581.135 | 0.1652 | -0.9658 | 0.4426 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11854.135 | 0.9316 | 0.8953 | 1.3170 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11854.135 | 0.8923 | 0.8342 | 1.3170 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11854.135 | 0.9261 | 0.8868 | 1.3170 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11854.135 | 0.9393 | 0.9071 | 1.3170 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11854.135 | 0.9624 | 0.9426 | 1.3170 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11854.135 | 0.9343 | 0.8994 | 1.3170 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11854.135 | 0.6970 | 0.5206 | 1.3170 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11854.135 | 0.1856 | -0.4433 | 1.3170 | |
| BT-20 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11854.135 | 0.1137 | -0.6161 | 1.3170 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12056.135 | 0.9282 | 0.8469 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12056.135 | 0.9065 | 0.8008 | 0.9361 |