Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12509.135 | 0.5174 | 0.2371 | 1.3717 | |
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12509.135 | 0.4679 | 0.1496 | 1.3717 | |
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12509.135 | 0.3656 | -0.0395 | 1.3717 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12566.135 | 0.9386 | 0.9242 | 1.6384 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12566.135 | 1.0229 | 1.0278 | 1.6384 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12566.135 | 0.9615 | 0.9527 | 1.6384 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12566.135 | 0.8518 | 0.8134 | 1.6384 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12566.135 | 0.6343 | 0.5148 | 1.6384 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12566.135 | 0.4365 | 0.2058 | 1.6384 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12566.135 | 0.3165 | -0.0090 | 1.6384 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12566.135 | 0.2797 | -0.0809 | 1.6384 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12566.135 | 0.1087 | -0.4838 | 1.6384 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12224.135 | 0.9754 | 0.9522 | 1.0314 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12224.135 | 0.9272 | 0.8586 | 1.0314 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12224.135 | 0.9995 | 0.9990 | 1.0314 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12224.135 | 1.0098 | 1.0189 | 1.0314 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12224.135 | 0.9249 | 0.8542 | 1.0314 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12224.135 | 0.5971 | 0.2132 | 1.0314 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12224.135 | 0.4943 | 0.0101 | 1.0314 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12224.135 | 0.4506 | -0.0768 | 1.0314 | |
| 600MPE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12224.135 | 0.3870 | -0.2034 | 1.0314 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10880.148 | 0.9781 | 0.9746 | 1.7293 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10880.148 | 0.9991 | 0.9989 | 1.7293 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10880.148 | 0.9795 | 0.9762 | 1.7293 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10880.148 | 0.9702 | 0.9654 | 1.7293 |