Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 66.7 | uM | 11939.145 | 0.0233 | -0.7857 | 1.6830 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 14149.189 | 0.9526 | 0.9562 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 14149.189 | 0.9526 | 0.9562 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.000853 | uM | 14149.189 | 0.8839 | 0.8903 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.000853 | uM | 14149.189 | 0.8839 | 0.8903 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.00427 | uM | 14149.189 | 0.9517 | 0.9553 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.00427 | uM | 14149.189 | 0.9517 | 0.9553 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.0213 | uM | 14149.189 | 0.9963 | 0.9966 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.0213 | uM | 14149.189 | 0.9963 | 0.9966 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.107 | uM | 14149.189 | 0.9483 | 0.9521 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.107 | uM | 14149.189 | 0.9483 | 0.9521 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.533 | uM | 14149.189 | 0.9457 | 0.9497 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.533 | uM | 14149.189 | 0.9457 | 0.9497 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 2.67 | uM | 14149.189 | 0.4440 | 0.3802 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 2.67 | uM | 14149.189 | 0.4440 | 0.3802 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 13.3 | uM | 14149.189 | 0.1717 | -0.1058 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 13.3 | uM | 14149.189 | 0.1717 | -0.1058 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 66.7 | uM | 14149.189 | 0.3829 | 0.2898 | 2.1888 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 66.7 | uM | 14149.189 | 0.3829 | 0.2898 | 2.1888 | |
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12509.135 | 0.9974 | 0.9963 | 1.3717 | |
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12509.135 | 1.0003 | 1.0004 | 1.3717 | |
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12509.135 | 1.0393 | 1.0570 | 1.3717 | |
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12509.135 | 0.9594 | 0.9405 | 1.3717 | |
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12509.135 | 0.8173 | 0.7265 | 1.3717 | |
| 184A1 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12509.135 | 0.7005 | 0.5429 | 1.3717 |