Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12056.135 | 0.9438 | 0.8802 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12056.135 | 0.9468 | 0.8866 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12056.135 | 0.8856 | 0.7566 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12056.135 | 0.7112 | 0.3896 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12056.135 | 0.6704 | 0.3047 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12056.135 | 0.5613 | 0.0792 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12056.135 | 0.5265 | 0.0078 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12178.135 | 1.0326 | 1.1197 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12178.135 | 1.0325 | 1.1194 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12178.135 | 1.0279 | 1.1021 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12178.135 | 1.0617 | 1.2288 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12178.135 | 0.9812 | 0.9326 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12178.135 | 0.8212 | 0.4002 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12178.135 | 0.7917 | 0.3105 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12178.135 | 0.6804 | -0.0038 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12178.135 | 0.6474 | -0.0898 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12291.135 | 0.8770 | 0.4975 | 0.4536 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12291.135 | 0.9149 | 0.6440 | 0.4536 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12291.135 | 1.0538 | 1.2450 | 0.4536 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12291.135 | 0.9613 | 0.8335 | 0.4536 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12291.135 | 0.8734 | 0.4841 | 0.4536 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12291.135 | 0.6613 | -0.1963 | 0.4536 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12291.135 | 0.5917 | -0.3710 | 0.4536 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12291.135 | 0.5472 | -0.4706 | 0.4536 | |
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12291.135 | 0.4180 | -0.7077 | 0.4536 |