Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 10998.154 | 0.9337 | 0.8232 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 10998.154 | 1.0275 | 1.0746 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 10998.154 | 0.9642 | 0.9040 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 10998.154 | 0.8840 | 0.6934 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 10998.154 | 0.4542 | -0.3104 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 10998.154 | 0.2963 | -0.6125 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 10998.154 | 0.3145 | -0.5800 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 10998.154 | 0.2273 | -0.7291 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12206.154 | 1.0301 | 1.0595 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12206.154 | 0.9245 | 0.8508 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12206.154 | 0.9946 | 0.9893 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12206.154 | 0.9750 | 0.9505 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12206.154 | 0.8527 | 0.7087 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12206.154 | 0.3974 | -0.1960 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12206.154 | 0.3137 | -0.3635 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12206.154 | 0.2774 | -0.4362 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12206.154 | 0.1965 | -0.5991 | 1.0125 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12594.167 | 1.0101 | 1.0143 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.000427 | uM | 12594.167 | 1.0223 | 1.0315 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.00213 | uM | 12594.167 | 0.9965 | 0.9950 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0107 | uM | 12594.167 | 0.9768 | 0.9670 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0533 | uM | 12594.167 | 0.6144 | 0.4158 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.267 | uM | 12594.167 | 0.3051 | -0.1383 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 1.33 | uM | 12594.167 | 0.0091 | -0.9284 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 6.67 | uM | 12594.167 | 0.0089 | -0.9295 | 1.4099 |