Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 11938.154 | 0.8617 | 0.5834 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 11938.154 | 0.9579 | 0.8696 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 11938.154 | 0.9280 | 0.7787 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 11938.154 | 0.9550 | 0.8606 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 11938.154 | 0.6402 | -0.0064 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 11938.154 | 0.1262 | -0.9222 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 11938.154 | 0.1042 | -0.9424 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 11938.154 | 0.0478 | -0.9831 | 0.6375 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11660.154 | 0.9448 | 0.8826 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 11660.154 | 0.9223 | 0.8349 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 11660.154 | 0.9602 | 0.9153 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 11660.154 | 0.9285 | 0.8481 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 11660.154 | 0.9563 | 0.9071 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 11660.154 | 0.7874 | 0.5506 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 11660.154 | 0.2425 | -0.5577 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 11660.154 | 0.1265 | -0.7790 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 11660.154 | 0.1257 | -0.7804 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12003.167 | 0.9639 | 0.9351 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12003.167 | 0.9181 | 0.8525 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12003.167 | 0.9521 | 0.9139 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12003.167 | 0.8462 | 0.7220 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12003.167 | 0.7259 | 0.5009 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12003.167 | 0.6861 | 0.4268 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12003.167 | 0.4109 | -0.0987 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12003.167 | 0.3604 | -0.1987 | 1.1158 |