Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 10939.154 | 0.9613 | 0.9538 | 1.6876 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 10939.154 | 0.9502 | 0.9404 | 1.6876 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 10939.154 | 0.2317 | -0.1591 | 1.6876 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 10939.154 | 0.0114 | -0.8589 | 1.6876 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 10939.154 | 0.0239 | -0.7810 | 1.6876 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 10939.154 | 0.0169 | -0.8220 | 1.6876 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12608.167 | 0.9992 | 0.9987 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.000427 | uM | 12608.167 | 0.9927 | 0.9885 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.00213 | uM | 12608.167 | 1.0204 | 1.0322 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0107 | uM | 12608.167 | 0.9915 | 0.9866 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0533 | uM | 12608.167 | 0.9082 | 0.8538 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.267 | uM | 12608.167 | 0.4028 | -0.0237 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 1.33 | uM | 12608.167 | 0.0143 | -0.9299 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 6.67 | uM | 12608.167 | 0.0137 | -0.9323 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 33.3 | uM | 12608.167 | 0.0147 | -0.9282 | 1.2681 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10754.154 | 1.0058 | 1.0083 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 10754.154 | 0.9306 | 0.8993 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 10754.154 | 0.9950 | 0.9929 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 10754.154 | 0.9273 | 0.8945 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 10754.154 | 0.8607 | 0.7959 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 10754.154 | 0.4668 | 0.1577 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 10754.154 | 0.0705 | -0.7020 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 10754.154 | 0.0494 | -0.7691 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 10754.154 | 0.0581 | -0.7406 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11938.154 | 0.9856 | 0.9551 | 0.6375 |