Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12192.154 | 0.9886 | 0.9579 | 0.5377 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12192.154 | 1.0536 | 1.2039 | 0.5377 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12192.154 | 0.9957 | 0.9841 | 0.5377 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12192.154 | 0.4715 | -0.5059 | 0.5377 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12192.154 | 0.0987 | -0.9731 | 0.5377 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000256 | uM | 10577.142 | 0.9519 | 0.9090 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00128 | uM | 10577.142 | 0.9031 | 0.8163 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0064 | uM | 10577.142 | 0.9262 | 0.8602 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.032 | uM | 10577.142 | 0.9459 | 0.8975 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.16 | uM | 10577.142 | 0.8775 | 0.7677 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.8 | uM | 10577.142 | 0.8742 | 0.7614 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 4 | uM | 10577.142 | 0.9136 | 0.8363 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 20 | uM | 10577.142 | 0.1337 | -0.7012 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 100 | uM | 10577.142 | 0.0121 | -0.9691 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10937.154 | 0.9838 | 0.9788 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 10937.154 | 0.9658 | 0.9550 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 10937.154 | 0.9448 | 0.9271 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 10937.154 | 1.0075 | 1.0098 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 10937.154 | 0.9504 | 0.9346 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 10937.154 | 0.9761 | 0.9686 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 10937.154 | 0.9310 | 0.9086 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 10937.154 | 0.7308 | 0.6292 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 10937.154 | 0.0085 | -0.9117 | 1.5291 | |
| HCC38 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000256 | uM | 10578.142 | 0.9760 | 0.9733 | 1.8112 | |
| HCC38 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00128 | uM | 10578.142 | 0.8687 | 0.8505 | 1.8112 |