Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 12400.166 | 0.9685 | 0.9542 | 1.3827 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 12400.166 | 0.9796 | 0.9704 | 1.3827 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 12400.166 | 0.9459 | 0.9212 | 1.3827 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 12400.166 | 0.9711 | 0.9580 | 1.3827 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 12400.166 | 0.9902 | 0.9858 | 1.3827 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 12400.166 | 1.0546 | 1.0784 | 1.3827 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 12400.166 | 1.0181 | 1.0261 | 1.3827 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 12400.166 | 0.6274 | 0.4276 | 1.3827 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10694.149 | 1.0244 | 1.0206 | 2.3563 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 10694.149 | 0.9902 | 0.9917 | 2.3563 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 10694.149 | 1.0076 | 1.0064 | 2.3563 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 10694.149 | 0.9718 | 0.9759 | 2.3563 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 10694.149 | 1.0076 | 1.0064 | 2.3563 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 10694.149 | 0.9404 | 0.9485 | 2.3563 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 10694.149 | 0.9844 | 0.9867 | 2.3563 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 10694.149 | 0.8966 | 0.9095 | 2.3563 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 10694.149 | 0.3639 | 0.3024 | 2.3563 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10816.149 | 1.2326 | 2.1685 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10816.149 | 1.2218 | 2.1076 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10816.149 | 1.1463 | 1.7009 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10816.149 | 1.0325 | 1.1458 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10816.149 | 1.0661 | 1.3022 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10816.149 | 1.1371 | 1.6532 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10816.149 | 1.0533 | 1.2419 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10816.149 | 1.0763 | 1.3514 | 0.4545 |