Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 12178.161 | 1.0918 | 1.3319 | 0.5721 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 12178.161 | 1.0524 | 1.1867 | 0.5721 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 12178.161 | 1.0372 | 1.1319 | 0.5721 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 12178.161 | 0.9731 | 0.9069 | 0.5721 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 12178.161 | 0.9823 | 0.9385 | 0.5721 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 12178.161 | 0.2675 | -0.8005 | 0.5721 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12291.166 | 0.9480 | 0.8286 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 12291.166 | 0.9076 | 0.6998 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12291.166 | 1.0361 | 1.1225 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 12291.166 | 0.9120 | 0.7138 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 12291.166 | 0.8750 | 0.5987 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 12291.166 | 0.9765 | 0.9218 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 12291.166 | 0.8943 | 0.6581 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 12291.166 | 0.9039 | 0.6881 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 12291.166 | 0.7150 | 0.1392 | 0.5962 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10696.149 | 1.0131 | 1.0447 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10696.149 | 0.9216 | 0.7416 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10696.149 | 0.9874 | 0.9574 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10696.149 | 0.9728 | 0.9087 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10696.149 | 1.0120 | 1.0409 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10696.149 | 0.9678 | 0.8922 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10696.149 | 0.9598 | 0.8658 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10696.149 | 0.9196 | 0.7354 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10696.149 | 0.6765 | 0.0320 | 0.5906 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 11855.161 | 0.9623 | 0.8749 | 0.5957 |