Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 11855.161 | 0.8987 | 0.6718 | 0.5957 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 11855.161 | 0.9822 | 0.9407 | 0.5957 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 11855.161 | 0.9773 | 0.9244 | 0.5957 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 11855.161 | 0.9328 | 0.7795 | 0.5957 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 11855.161 | 0.9361 | 0.7900 | 0.5957 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 11855.161 | 0.8817 | 0.6190 | 0.5957 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 11855.161 | 0.8835 | 0.6245 | 0.5957 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 11855.161 | 0.6976 | 0.0925 | 0.5957 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12305.166 | 0.9661 | 0.9768 | 2.9556 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 12305.166 | 0.9488 | 0.9647 | 2.9556 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 12305.166 | 0.9405 | 0.9589 | 2.9556 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 12305.166 | 0.9707 | 0.9800 | 2.9556 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 12305.166 | 0.9489 | 0.9648 | 2.9556 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 12305.166 | 1.0752 | 1.0497 | 2.9556 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 12305.166 | 1.0245 | 1.0165 | 2.9556 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 12305.166 | 1.1787 | 1.1144 | 2.9556 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 12305.166 | 0.7848 | 0.8426 | 2.9556 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10473.137 | 1.0962 | 1.1690 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10473.137 | 0.9910 | 0.9840 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10473.137 | 0.9583 | 0.9261 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10473.137 | 1.0247 | 1.0435 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10473.137 | 1.0655 | 1.1153 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10473.137 | 1.0300 | 1.0530 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10473.137 | 1.1107 | 1.1943 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10473.137 | 1.0318 | 1.0560 | 1.1322 |