Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10473.137 | 0.9172 | 0.8531 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10755.149 | 0.9364 | 0.8689 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10755.149 | 0.8889 | 0.7710 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10755.149 | 0.9902 | 0.9798 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10755.149 | 0.9652 | 0.9283 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10755.149 | 0.9276 | 0.8507 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10755.149 | 0.9688 | 0.9356 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10755.149 | 0.9412 | 0.8788 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10755.149 | 0.9424 | 0.8811 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10755.149 | 0.7589 | 0.5042 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 12070.161 | 1.0130 | 1.0201 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 12070.161 | 0.9421 | 0.9096 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 12070.161 | 1.0000 | 1.0000 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 12070.161 | 1.0682 | 1.1049 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 12070.161 | 1.0067 | 1.0104 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 12070.161 | 1.0024 | 1.0038 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 12070.161 | 0.8785 | 0.8089 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 12070.161 | 1.0087 | 1.0135 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 12070.161 | 0.2238 | -0.3731 | 1.2903 | |
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000128 | uM | 12112.161 | 1.0080 | 1.0093 | 1.7182 | |
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00064 | uM | 12112.161 | 0.9955 | 0.9948 | 1.7182 | |
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0032 | uM | 12112.161 | 1.0608 | 1.0699 | 1.7182 | |
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.016 | uM | 12112.161 | 1.0608 | 1.0699 | 1.7182 | |
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.08 | uM | 12112.161 | 0.9443 | 0.9343 | 1.7182 | |
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.4 | uM | 12112.161 | 1.0729 | 1.0836 | 1.7182 |