Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7902.001 | 0.6454 | 0.5951 | 1.9359 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7902.001 | 0.4241 | 0.2840 | 1.9359 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7902.001 | 0.5596 | 0.4819 | 1.9359 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7902.001 | 0.6072 | 0.5457 | 1.9359 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7902.001 | 0.3939 | 0.2360 | 1.9359 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10266.001 | 1.1600 | 1.4001 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10266.001 | 0.7873 | 0.4909 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10266.001 | 1.1183 | 1.2946 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10266.001 | 0.8321 | 0.5956 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10266.001 | 0.6040 | 0.0765 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10266.001 | 0.4999 | -0.1469 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10266.001 | 0.6005 | 0.0688 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10266.001 | 0.6404 | 0.1567 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10266.001 | 0.4782 | -0.1922 | 0.8138 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9708.001 | 1.0608 | 1.1199 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9708.001 | 1.1105 | 1.2177 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9708.001 | 1.0079 | 1.0156 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9708.001 | 1.0490 | 1.0965 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9708.001 | 0.5566 | 0.1223 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9708.001 | 0.4002 | -0.1893 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9708.001 | 0.4952 | 0.0002 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9708.001 | 0.5962 | 0.2010 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9708.001 | 0.4749 | -0.0402 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9723.001 | 1.0302 | 1.0644 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9723.001 | 0.9546 | 0.9036 | 0.9400 |