Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9551.001 | 0.3496 | 0.3534 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9551.001 | 0.4223 | 0.4519 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9551.001 | 0.3316 | 0.3271 | 2.6913 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7871.001 | 1.0663 | 1.1284 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7871.001 | 0.9869 | 0.9747 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7871.001 | 1.0584 | 1.1131 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7871.001 | 1.0239 | 1.0464 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7871.001 | 0.7400 | 0.4936 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7871.001 | 0.5742 | 0.1677 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7871.001 | 0.5668 | 0.1531 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7871.001 | 0.6140 | 0.2462 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7871.001 | 0.3120 | -0.3537 | 1.0311 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7872.001 | 0.6241 | 0.4145 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7872.001 | 0.9860 | 0.9793 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7872.001 | 0.9209 | 0.8825 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7872.001 | 0.8180 | 0.7255 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7872.001 | 0.6835 | 0.5122 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7872.001 | 0.6570 | 0.4688 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7872.001 | 0.6495 | 0.4566 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7872.001 | 0.6244 | 0.4150 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7872.001 | 0.2122 | -0.3597 | 1.3610 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9566.001 | 1.0342 | 1.0321 | 2.1122 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9566.001 | 0.9842 | 0.9849 | 2.1122 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9566.001 | 1.0747 | 1.0694 | 2.1122 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9566.001 | 0.9913 | 0.9918 | 2.1122 |