Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7833.001 | 0.3620 | -0.2423 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7834.001 | 0.9561 | 0.9561 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7834.001 | 0.9972 | 0.9972 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7834.001 | 1.0291 | 1.0286 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7834.001 | 0.9796 | 0.9798 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7834.001 | 0.7012 | 0.6779 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7834.001 | 0.4366 | 0.3275 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7834.001 | 0.4667 | 0.3719 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7834.001 | 0.4233 | 0.3073 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7834.001 | 0.3757 | 0.2323 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10262.001 | 1.0198 | 1.0653 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10262.001 | 1.0233 | 1.0769 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10262.001 | 1.0236 | 1.0779 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10262.001 | 0.9220 | 0.7509 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10262.001 | 0.7603 | 0.2767 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10262.001 | 0.6511 | -0.0096 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10262.001 | 0.7138 | 0.1512 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10262.001 | 0.7040 | 0.1255 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10262.001 | 0.6018 | -0.1295 | 0.6105 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7837.001 | 1.1729 | 1.2189 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7837.001 | 1.0997 | 1.1276 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7837.001 | 1.0829 | 1.1064 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7837.001 | 0.8571 | 0.8089 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7837.001 | 0.1846 | -0.3344 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7837.001 | 0.1039 | -0.5423 | 1.5358 |