Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9158.001 | 0.9721 | 0.9206 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9158.001 | 1.0383 | 1.1107 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9158.001 | 1.0434 | 1.1255 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9158.001 | 0.9185 | 0.7709 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9158.001 | 0.8261 | 0.5215 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9158.001 | 0.7683 | 0.3716 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9158.001 | 0.6553 | 0.0923 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9158.001 | 0.0191 | -0.9931 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9163.001 | 0.9689 | 0.8828 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9163.001 | 1.0366 | 1.1426 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9163.001 | 1.0340 | 1.1323 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9163.001 | 1.0151 | 1.0583 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9163.001 | 0.8458 | 0.4519 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9163.001 | 0.7387 | 0.1205 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9163.001 | 0.6858 | -0.0281 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9163.001 | 0.6716 | -0.0663 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9163.001 | 0.4005 | -0.6527 | 0.5227 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7801.001 | 1.0348 | 1.1306 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7801.001 | 1.0197 | 1.0735 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7801.001 | 1.0715 | 1.2729 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7801.001 | 1.0093 | 1.0344 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7801.001 | 0.8179 | 0.3784 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7801.001 | 0.8429 | 0.4577 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7801.001 | 0.7372 | 0.1374 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7801.001 | 0.7825 | 0.2701 | 0.5402 |