Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9347.001 | 0.9957 | 0.9942 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9347.001 | 1.0263 | 1.0349 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9347.001 | 1.0064 | 1.0085 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9347.001 | 0.9082 | 0.8757 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9347.001 | 0.6363 | 0.4797 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9347.001 | 0.6374 | 0.4814 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9347.001 | 0.6463 | 0.4951 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9347.001 | 0.4539 | 0.1814 | 1.5003 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9376.001 | 0.9418 | 0.9356 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9376.001 | 0.9596 | 0.9555 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9376.001 | 1.0128 | 1.0139 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9376.001 | 0.9636 | 0.9599 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9376.001 | 0.5375 | 0.4250 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9376.001 | 0.2478 | -0.0663 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9376.001 | 0.2664 | -0.0287 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9376.001 | 0.3004 | 0.0372 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9376.001 | 0.1598 | -0.2653 | 1.8315 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7833.001 | 1.0314 | 1.0599 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7833.001 | 0.7131 | 0.4480 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7833.001 | 0.8417 | 0.6964 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7833.001 | 0.6233 | 0.2732 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7833.001 | 0.6518 | 0.3288 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7833.001 | 0.4241 | -0.1187 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7833.001 | 0.4551 | -0.0571 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7833.001 | 0.5472 | 0.1243 | 1.0468 |