Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9146.001 | 0.9292 | 0.8891 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9146.001 | 0.2267 | -0.3683 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9146.001 | 0.1147 | -0.6279 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9146.001 | 0.1581 | -0.5225 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9146.001 | 0.3120 | -0.1906 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9146.001 | 0.0231 | -0.8927 | 1.2878 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7798.001 | 1.0502 | 1.0729 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7798.001 | 1.0227 | 1.0332 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7798.001 | 1.0576 | 1.0836 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7798.001 | 0.9665 | 0.9507 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7798.001 | 0.9640 | 0.9470 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7798.001 | 0.8449 | 0.7679 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7798.001 | 0.8921 | 0.8396 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7798.001 | 0.7936 | 0.6888 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7798.001 | 0.1546 | -0.4898 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9157.001 | 1.0622 | 1.1355 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9157.001 | 0.9161 | 0.8184 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9157.001 | 1.1171 | 1.2556 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9157.001 | 1.0534 | 1.1163 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9157.001 | 0.8855 | 0.7526 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9157.001 | 0.8648 | 0.7082 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9157.001 | 0.8234 | 0.6196 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9157.001 | 0.8003 | 0.5703 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9157.001 | 0.2121 | -0.6286 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9158.001 | 0.9147 | 0.7605 | 0.6988 |