Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9120.001 | 0.8447 | 0.5221 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9120.001 | 0.9816 | 0.9409 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9120.001 | 1.1022 | 1.3410 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9120.001 | 0.8300 | 0.4795 | 0.6180 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7793.001 | 1.0185 | 1.0321 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7793.001 | 0.9915 | 0.9852 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7793.001 | 1.0428 | 1.0742 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7793.001 | 1.0274 | 1.0476 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7793.001 | 0.1567 | -0.6005 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7793.001 | 0.0718 | -0.7973 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7793.001 | 0.1035 | -0.7215 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7793.001 | 0.2683 | -0.3624 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7793.001 | 0.0950 | -0.7415 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9035.001 | 0.8828 | 0.9000 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9035.001 | 1.0181 | 1.0148 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9035.001 | 0.9709 | 0.9758 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9035.001 | 0.8593 | 0.8790 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9035.001 | 0.1738 | -0.0268 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9035.001 | 0.0603 | -0.3707 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9035.001 | 0.0633 | -0.3579 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9035.001 | 0.1553 | -0.0708 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9035.001 | 0.1487 | -0.0875 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9146.001 | 0.8950 | 0.8349 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9146.001 | 1.0614 | 1.0947 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9146.001 | 0.9542 | 0.9285 | 1.2878 |