Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 10139.001 | 0.3734 | -0.4779 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 10139.001 | 0.1318 | -0.8738 | 0.7336 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7917.001 | 0.9033 | 0.9322 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7917.001 | 1.0061 | 1.0041 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7917.001 | 0.6948 | 0.7676 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7917.001 | 0.2041 | 0.1668 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7917.001 | 0.1336 | 0.0104 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7917.001 | 0.1114 | -0.0499 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7917.001 | 0.1728 | 0.1027 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7917.001 | 0.1971 | 0.1529 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7917.001 | 0.0953 | -0.0990 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9830.001 | 0.9952 | 0.9952 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9830.001 | 1.0584 | 1.0566 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9830.001 | 0.9215 | 0.9213 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9830.001 | 0.9801 | 0.9804 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9830.001 | 0.2578 | 0.0272 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 9830.001 | 0.1116 | -0.3194 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 9830.001 | 0.1232 | -0.2853 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 9830.001 | 0.1676 | -0.1688 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 9830.001 | 0.1730 | -0.1557 | 2.0346 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7918.001 | 1.1533 | 1.1015 | 2.8818 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7918.001 | 1.1625 | 1.1073 | 2.8818 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7918.001 | 1.1563 | 1.1034 | 2.8818 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7918.001 | 1.0777 | 1.0526 | 2.8818 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7918.001 | 0.3270 | 0.3569 | 2.8818 |