Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12291.157 | 0.9937 | 0.9756 | 0.5161 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12291.157 | 0.8871 | 0.5858 | 0.5161 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12291.157 | 0.9633 | 0.8600 | 0.5161 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12291.157 | 0.9128 | 0.6757 | 0.5161 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10696.151 | 0.9784 | 0.8848 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10696.151 | 0.9872 | 0.9311 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10696.151 | 0.9412 | 0.6970 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10696.151 | 0.9752 | 0.8685 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10696.151 | 1.0045 | 1.0245 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10696.151 | 0.9371 | 0.6770 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10696.151 | 0.9628 | 0.8046 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10696.151 | 0.9358 | 0.6710 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10696.151 | 0.9274 | 0.6306 | 0.3690 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 11855.157 | 0.8673 | 0.6735 | 0.7986 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 11855.157 | 0.9041 | 0.7629 | 0.7986 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 11855.157 | 0.8978 | 0.7475 | 0.7986 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 11855.157 | 0.8839 | 0.7137 | 0.7986 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 11855.157 | 0.8988 | 0.7500 | 0.7986 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11855.157 | 0.8997 | 0.7521 | 0.7986 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 11855.157 | 0.9242 | 0.8121 | 0.7986 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 11855.157 | 0.9028 | 0.7596 | 0.7986 | |
| BT-483 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 11855.157 | 0.9440 | 0.8608 | 0.7986 | |
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12305.157 | 0.8798 | 0.9163 | 2.9955 | |
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12305.157 | 0.8776 | 0.9147 | 2.9955 | |
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12305.157 | 0.9531 | 0.9682 | 2.9955 |