Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 12580.171 | 0.9835 | 0.9837 | 2.0272 | |
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 12580.171 | 1.0219 | 1.0215 | 2.0272 | |
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 12580.171 | 1.0121 | 1.0119 | 2.0272 | |
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 12580.171 | 0.9862 | 0.9864 | 2.0272 | |
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.267 | uM | 12580.171 | 0.9538 | 0.9539 | 2.0272 | |
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 1.33 | uM | 12580.171 | 0.8916 | 0.8900 | 2.0272 | |
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 6.67 | uM | 12580.171 | 0.8101 | 0.8026 | 2.0272 | |
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 33.3 | uM | 12580.171 | 0.7165 | 0.6967 | 2.0272 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 11056.151 | 0.9750 | 0.9834 | 3.0292 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 11056.151 | 0.9713 | 0.9809 | 3.0292 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 11056.151 | 1.0006 | 1.0004 | 3.0292 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 11056.151 | 0.9306 | 0.9530 | 3.0292 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 11056.151 | 0.6782 | 0.7593 | 3.0292 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.267 | uM | 11056.151 | 0.4377 | 0.5226 | 3.0292 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 1.33 | uM | 11056.151 | 0.4561 | 0.5434 | 3.0292 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 6.67 | uM | 11056.151 | 0.4485 | 0.5349 | 3.0292 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 33.3 | uM | 11056.151 | 0.5064 | 0.5977 | 3.0292 | |
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12254.157 | 0.9995 | 0.9994 | 1.6969 | |
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12254.157 | 1.0479 | 1.0559 | 1.6969 | |
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12254.157 | 1.0082 | 1.0096 | 1.6969 | |
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12254.157 | 1.0544 | 1.0634 | 1.6969 | |
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12254.157 | 0.9510 | 0.9417 | 1.6969 | |
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12254.157 | 0.8704 | 0.8430 | 1.6969 | |
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 2 | uM | 12254.157 | 0.8893 | 0.8664 | 1.6969 | |
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 10 | uM | 12254.157 | 0.8581 | 0.8275 | 1.6969 |