Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12305.157 | 0.8535 | 0.8970 | 2.9955 | |
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12305.157 | 0.8275 | 0.8775 | 2.9955 | |
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12305.157 | 0.6537 | 0.7354 | 2.9955 | |
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 2 | uM | 12305.157 | 0.5778 | 0.6653 | 2.9955 | |
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10 | uM | 12305.157 | 0.6488 | 0.7310 | 2.9955 | |
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 50 | uM | 12305.157 | 0.5434 | 0.6315 | 2.9955 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10473.139 | 0.9120 | 0.8529 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10473.139 | 0.9445 | 0.9074 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10473.139 | 0.9522 | 0.9204 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10473.139 | 0.9669 | 0.9450 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10473.139 | 0.9867 | 0.9779 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10473.139 | 0.9680 | 0.9467 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10473.139 | 0.9148 | 0.8576 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10473.139 | 0.8056 | 0.6716 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10473.139 | 0.8233 | 0.7020 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10755.151 | 0.9529 | 0.8638 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10755.151 | 0.9538 | 0.8665 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10755.151 | 0.9617 | 0.8892 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10755.151 | 0.9250 | 0.7848 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10755.151 | 0.9838 | 0.9528 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10755.151 | 0.9283 | 0.7940 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10755.151 | 0.9227 | 0.7782 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10755.151 | 0.8869 | 0.6785 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10755.151 | 0.8448 | 0.5632 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12070.157 | 0.9570 | 0.9297 | 1.2286 |