Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12070.157 | 0.9752 | 0.9595 | 1.2286 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12070.157 | 0.9248 | 0.8767 | 1.2286 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12070.157 | 1.0004 | 1.0006 | 1.2286 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12070.157 | 1.0071 | 1.0116 | 1.2286 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12070.157 | 0.8816 | 0.8051 | 1.2286 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12070.157 | 0.9066 | 0.8466 | 1.2286 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12070.157 | 0.8333 | 0.7241 | 1.2286 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12070.157 | 0.8110 | 0.6864 | 1.2286 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12112.157 | 0.8997 | 0.8995 | 2.0505 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12112.157 | 0.8577 | 0.8557 | 2.0505 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12112.157 | 0.9220 | 0.9224 | 2.0505 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12112.157 | 0.9090 | 0.9091 | 2.0505 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12112.157 | 0.9212 | 0.9215 | 2.0505 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12112.157 | 0.8024 | 0.7964 | 2.0505 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 2 | uM | 12112.157 | 0.7129 | 0.6957 | 2.0505 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10 | uM | 12112.157 | 0.6577 | 0.6303 | 2.0505 | |
| HCC1143 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 50 | uM | 12112.157 | 0.6472 | 0.6176 | 2.0505 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10518.139 | 0.9882 | 0.9810 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10518.139 | 0.9960 | 0.9936 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10518.139 | 0.9309 | 0.8875 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10518.139 | 0.9670 | 0.9465 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10518.139 | 0.9828 | 0.9722 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10518.139 | 0.8449 | 0.7451 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10518.139 | 0.5895 | 0.3044 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10518.139 | 0.3875 | -0.0710 | 1.2366 |