Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7456.067 | 0.9771 | 0.9755 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7456.067 | 0.9716 | 0.9696 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7456.067 | 1.0034 | 1.0036 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7456.067 | 0.0505 | -0.5916 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7456.067 | 0.0336 | -0.6712 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7456.067 | 0.0393 | -0.6426 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7456.067 | 0.0284 | -0.6991 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7456.067 | 0.0062 | -0.8657 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7457.067 | 1.0022 | 1.0024 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7457.067 | 0.9747 | 0.9726 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7457.067 | 0.9145 | 0.9061 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7457.067 | 0.9273 | 0.9203 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7457.067 | 0.0705 | -0.5202 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7457.067 | 0.0575 | -0.5703 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7457.067 | 0.0543 | -0.5833 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7457.067 | 0.0420 | -0.6370 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7457.067 | 0.0031 | -0.9101 | 1.8574 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7458.067 | 1.0187 | 1.0660 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7458.067 | 0.9920 | 0.9719 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7458.067 | 0.9904 | 0.9665 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7458.067 | 0.7591 | 0.2346 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7458.067 | 0.2800 | -0.7846 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7458.067 | 0.2707 | -0.7969 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7458.067 | 0.3025 | -0.7533 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7458.067 | 0.0753 | -0.9783 | 0.5714 |