Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5903.067 | 0.8058 | 0.6847 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5903.067 | 0.3590 | -0.1140 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 5903.067 | 0.2292 | -0.3798 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 5903.067 | 0.3097 | -0.2120 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 5903.067 | 0.2897 | -0.2527 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 5903.067 | 0.0019 | -0.9863 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5904.067 | 1.0928 | 1.1781 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5904.067 | 0.9668 | 0.9362 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5904.067 | 0.9734 | 0.9487 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5904.067 | 0.8595 | 0.7289 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5904.067 | 0.2854 | -0.4011 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 5904.067 | 0.2798 | -0.4125 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 5904.067 | 0.3099 | -0.3518 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 5904.067 | 0.2801 | -0.4119 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 5904.067 | 0.0017 | -0.9957 | 1.0398 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5905.067 | 1.0975 | 1.2469 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5905.067 | 1.0166 | 1.0416 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5905.067 | 1.0730 | 1.1842 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5905.067 | 0.9955 | 0.9888 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5905.067 | 0.6413 | 0.1472 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5905.067 | 0.4750 | -0.2122 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5905.067 | 0.5173 | -0.1235 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5905.067 | 0.0343 | -0.9706 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5905.067 | 0.0063 | -0.9965 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5906.067 | 1.0170 | 1.0500 | 0.6838 |