Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5906.067 | 1.0680 | 1.2020 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5906.067 | 1.0437 | 1.1291 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5906.067 | 1.0230 | 1.0678 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5906.067 | 0.8677 | 0.6251 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5906.067 | 0.4355 | -0.4071 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5906.067 | 0.4512 | -0.3755 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5906.067 | 0.0765 | -0.9534 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5906.067 | 0.0084 | -0.9982 | 0.6838 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5908.067 | 0.7608 | 0.1752 | 0.5143 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5908.067 | 0.9156 | 0.6850 | 0.5143 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5908.067 | 0.9713 | 0.8898 | 0.5143 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5908.067 | 0.9518 | 0.8170 | 0.5143 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5908.067 | 0.8529 | 0.4679 | 0.5143 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5908.067 | 0.7939 | 0.2767 | 0.5143 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5908.067 | 0.7858 | 0.2515 | 0.5143 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5908.067 | 0.5748 | -0.3186 | 0.5143 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5908.067 | 0.0103 | -0.9997 | 0.5143 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5909.067 | 1.0763 | 1.0519 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5909.067 | 1.1119 | 1.0753 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5909.067 | 1.0337 | 1.0232 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5909.067 | 1.1390 | 1.0928 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5909.067 | 0.5329 | 0.6061 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 5909.067 | 0.3100 | 0.3297 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 5909.067 | 0.3399 | 0.3732 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 5909.067 | 0.3267 | 0.3543 | 2.8695 |